Is Endotoxin Septic Shock from Leaky Gut Effectually the Bugaboo COVID?
MODERN ALCHEMY HAS MADE INTESTINAL FOOD POISONING INTO COVID-19
PURE OPINION - NOT MEDICAL ADVICE
If endotoxins get into the blood stream, fever, shock, and organ failure may occur. As little as 1 mg of intravenous endotoxins can have lethal consequences. The presence of endotoxins in the blood (endotoxemia) typically leads to hypotension, respiratory failure, and reduced oxygen delivery. Strong endotoxemia can lead to sepsis and eventually death.
What are Endotoxins? Dr.Tobias Pusterla, BMG Labtech
Normal metabolism entails the breaking down of ingested food and the killing of any bacteria by stomach acids in the gut when the acid level is less than 3 (more acidic), or if raised to 4 (less acidic), can result in bacterial overgrowth. Gastric acid is stimulated by histamine release and can kill bacteria within 15 minutes. Acid deficiency can be acquired by malnutrition (lack of folate, zinc and vitamin B-12) or thyroid issues.
Broken down nutrients from the stomach acid normally enter the bloodstream through the intestinal lining. Leaky gut is defined as a condition where the lining of human intestines have become too permeable, mainly from eating lectin proteins that bore through gut lining such as beans, peanuts, French fries, fruits, wheat, and other grains. Other contributing factors include use of steroids, drugs, conventional pain relievers, fast food deficient in enzymes, and deficiency of vitamins A and D. While cigarettes are reportedly high in endotoxins, nicotine lessens the symptoms of endotoxic shock. Regular smokers have the lowest death rate from the bugaboo COVID-19. Large doses of endotoxic alcohol (ethanol) does not increase liver disease. There is no statistical association of alcohol consumption and COVID-19.
Gut leakiness can allow excessively large, unbroken-down food particles, non-nutrient molecules called metabolites, or dead bacterial cells called endotoxins to permeate through the intestinal lining that go directly into the bloodstream instead of to the waste system. The definition of deadly sepsis is blood poisoning, so endotoxins can be septicemic. Permeation of endotoxins into the bloodstream can cause inflammation, fatigue, brain fog, diarrhea, and what is called auto-immune reaction. Normal metabolism facilitates permeation across the intestinal barrier into the bloodstream of smaller and less-toxic particles.
Alternatively, endotoxins from airborne dust, manure, industrial soot, putrefied food, dog dander, humidity, and smoke can cause chest tightness, cough, shortness of breath, fever, and wheezing that is often misattributed to a respiratory virus. They also can manifest as flu, urinary tract infections, skin rashes, and shingles-like nerve pain. Healthy, non-toxic food can also turn toxic if it spoils or putrefies in the body. This can be mistaken for an infection caused by a bugaboo virus, that doesn’t exist, instead of from a dead bacterial debris known as an endotoxin.
What is exotoxin and endotoxin? Exotoxins (external toxins) are produced inside potentially pathogenic bacteria, most commonly resilient walled bacteria, as part of their growth and metabolism. The Exotoxins are then released into its surroundings in the body following their death. Exotoxins can also include airborne toxins (asthma).
Conversely, Endotoxins (interior toxins) are lipopolysaccharides (LPS’s or sugar molecule wrapped in fat) that are part of the outer part of resilient walled (gram negative) bacteria. The endotoxins are let loose from their host when the bacteria die and the cell wall breaks apart (source: MicrobiologyInfo.com).
An Endotoxin is not an infectious particle, germ, or parasite-virus, it is active material from bacteria that can cause virulence. Airborne exposure to endotoxins can cause breathing difficulties, fever, and cough, often mistaken as solely a lung infection from a flu bug or “virus”. But endotoxins can be generated internally from dead bacteria exposed to antibiotics.
What virologists are seemingly and sometimes mistakenly describing with COVID is not the effects of a singular “germ” but the process of “virulence” where an organism (endotoxin or inner toxin) infects a host bacterium, or the bacteria resists being killed by a fungal antibiotic causing virulence. This resistance can occur many ways: membrane intrusion, toxic secretions, disabling enzymes, making docking ports for attachment to bacteria, forming biofilms or protective plasmid shells, or overgrowth. Highly resilient bacteria are called Gram Negative and more permeable bacteria are called Gram Positive.
To date, no serious diseases have been reported as affecting infants from endotoxin contaminated food.
Moreover, researchers have found an intriguing association between Blood Type A and susceptibility to infectious disease, vis-à-vis the bugaboo COVID-19.
Neither Germ Theory nor Terrain Theory adequately describe endotoxic shock as it is not purely a germ or environmentally caused but can be institutionally caused by antibiotics or dirty needles, as well as from gut permeation, ostensibly from health foods or from dehydration and fluid and C02 stagnation that increases the relative ratio of toxification.
As John Kellum of Spectral Medical, writes in an article titled “The Role of Endotoxin in Septic Shock”:
“Septic shock can be caused by a variety of mechanisms including direct effects of bacterial toxins such as endotoxin. Annually, approximately 5–7 million patients worldwide develop sepsis with very high endotoxin activity in the blood and more than half die. The term endotoxic septic shock has been used for these patients but it is important to emphasize that endotoxin may be a factor in all forms of septic shock including non-bacterial etiologies like COVID-19 since translocation of bacterial products is a common feature of septic shock. A pattern of organ failure including hepatic (liver) dysfunction, acute kidney injury and various forms of endothelial dysfunction ranging from disseminated intravascular coagulation to thrombotic microangiopathy characterize endotoxic septic shock. ...Across the globe sepsis is now estimated to result in more than 11 million deaths a year and septic shock, the most severe form, leaves nearly 40% of patients dead at hospital discharge…Rather than live bacteria, translocation of bacterial products from the gut is the dominant source of endotoxemia, and 70% of patients with septic shock and high endotoxin activity have (gram) negative (resilient) blood cultures and blood types.”
Food Sources of Endotoxin
Sample endotoxin content in foods (microgram/gram)
Ginseng -50.0% per gram
Licorice - 30.0
Seaweed – 21.2
Persimmon – 17.2
Brown rice – 10.0
Wheat bran – 8.8
Wheat germ – 7.5
Barley – 3.0
Shitake mushrooms- 2.0
Spinach 1.3
Mushroom Mycelium – 0.8
Kale – 0.2
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Ground Beef – 20 to 31,250
The amount of endotoxin per unit of weight in soy protein is four times more than that in beef, although meat and dairy products are misreported by the FDA as having higher levels of endotoxins than fruits and vegetables. Organic vegetables and fruits have no fewer endotoxins than non-organic.
Antibiotics can be endotoxin releasers as well as bacteria killers.
It must be stated that endotoxins cannot be merely counted because they do not conform to the “dose makes the poison” rule, in that they have a feedback loop that multiplies the dosage. Of course, any potential poison in the human body is relative and depends on the body’s hydration level and capability to clear toxins through its elimination systems. Congested arteries would have relatively higher endotoxins than clear arteries, even if the number of endotoxins were constant.
Endotoxin Antidotes, Treatments, Avoidances
Aspirin – Treatment with Acetylsalicylic Acid Reverses Endotoxin Tolerance in Humans in Vivo: A Randomized Placebo Controlled Study, Guus Leijte, MD, Critical Care Medicine, April 2019. This entails treatment only and not prophylaxis.
Vitamin A Deficiency – Vitamin A Prevents Lipopolysaccharide-Induced Injury on Tight Junctions in Mice, Wiley Online Library, Feb. 27, 2020.
DMSO Resin/Solvent – Toxin Eraser Endotoxin Removal Kit – DMSO tree solvent.
Dietary Fiber – Dietary Fiber Ameliorates Lipopolysaccharide-Induced Intestinal Barrier Function Damage in Piglets by Modulation of Intestinal Microbiome, Host-Microbial Interactions, April 6, 2021.
Glucocorticoids – The NIH weakly recommends Glucocorticoid hormones to reduce inflammation from sepsis, which have been called “unequivocally beneficial” for pneumonia (A Comparison Between SARS-COV-2 and Gram Negative Bacteria Induced Hyperinflammation and Sepsis). While many Glucocorticoids are synthetic (prednisolone), Cortisol is a natural GC. During intensive care, antithrombin alone, not combined with heparin, demonstrated positive results.
Heat – 250 degrees centigrade for 30 minutes kills endotoxins.
Acids/Alkalis - Acids or alkalis of at least 0.1 M strength can also be used to destroy endotoxin in laboratory scale. Very low concentrations of endotoxins (0.025 EU/ML) are in distilled water.
Leaky Gut Supplements: Butyrate, Propionate, Acetate, and Glutamine are rich sources of energy for intestinal wall cells.
Carrageenans – inhibit Endotoxin-induced inflammation in mice. But a 1977 mouse study found that Lethal Endotoxicity was increased by Carrageenans by 100 to 3,000 times. Carrageenan is an anticoagulant food additive.
Inhibition of Ibuprofen (aka cyclooxygenase). Endotoxin treatment presently involves fluid replacement, correction of acid-base abnormalities, augmentation of cardiovascular function, and inhibition of cyclooxygenase (Ibuprofen) activity. Recognition and Treatment of Encotoxemia, Veterinary Clinical North American Equine Practice, April 1988.
PMX-HP - Therapeutic Rationale for Endotoxin Removal with Polymyxin B Immobilized Fiber Column (PMX) for Septic Shock, Hisataka Shoji, International Journal of Molecular Science, Feb. 21,2023. Polymyxin B (an antibiotic used to treat pneumonia, sepsis, UTI’s, and meningitis) is covalently bound onto the surface of the polystyrene-based carrier fiber in PMX-DHP and inactivates the endotoxin in the blood without exerting toxicity. An antibiotic that does not trigger bacterial or fungal resistance (brand name Toraymyxin).
Moral Hazard
When symptoms of septic shock first present themselves to medical personnel in a hospital (not brought from home), it is impossible to separate the origin as being from bacteria-laced needles, from bacterial resistance to antibiotics, or from endotoxic food poisoning. Typically, all cases are assumed to be the worst-case scenario of deadly bacterial resistance or from contaminated needles, catheters, or breathing tubes. But, as indicated above, foodborne septic endotoxic shock can be simply treated with aspirin, fiber, and DMSO solvent. So, the percentage of cases that are foodborne endotoxic shock may be difficult to discern as there may be no practical or economic incentive to such diagnosis. This reflects the classic situation of a moral hazard where insurance companies are exposed to a moral hazard if the insured party or their caregivers are not honest. There is a marker for endotoxemia called Limulus Amebocyte Lystate (LAL) Test, however unreliable.
Untreated municipal drinking water has high concentrations of endotoxins (>4 ng/L) and plausibly H-Pylori bacteria requiring UV treatment, chemical sanitization, and charcoal filtration. There is no evidence of treated or untreated waste water causing anyone to become sick from COVID.
Evidence that most COVID Sepsis is Endotoxemic Shock
There is a tight correlation between endotoxin levels and severity of septic shock, organ dysfunction, and the risk of death. Up to 82% of patients with septic shock have endotoxemia…associated with significantly high lactate levels.
Out of 147 hospitalized patients, only 6 had severe COVID-19, with acute respiratory stress syndrome. Treatment included dialysis blood purification, and Polymyxin antibiotic which does not cause bacterial resistance. COVID-19 ICU Patients Treated as Endotoxemia all (100%) survived.
“Several clinical reports demonstrate significantly increased levels of endotoxins in the plasma of severely affected COVID-19 patients. Lipopolysaccharides (LPS) levels were investigated in a prospective study on 19 patients with severe pulmonary forms of COVID-19; almost 90% of them had increased LPS levels—40% demonstrated high and 30% demonstrated very high endotoxin levels. …6,492 hospitalized cases and over 1 million controls demonstrated that serum LBP (endotoxin) levels strongly correlate with the hospitalization rate of COVID-19 patients.
Fifty-five (90%) out of 61 patients received a second PMX-HA (blood purification) treatment, with a statistically significant difference between the two groups.
COVID-19 Vax Spike Protein as an Endotoxin Delivery System
Researcher Jeff Pain of Australia, says all COVID injections carry Lipopolysaccharide (Endotoxin) which is the cause of Cytosine Storm of molecules raining into human blood (see “Danger of Endotoxin in mRNA Injections”, October, 2023). No SARS-CoV-2 or COVID-19 virus or spike protein is necessary for this to occur. Nonetheless, the Australian government allows 100 times more endotoxins in jabs than epidurals and refuses to release Endotoxin Assay results. It is the Endotoxic jab that causes Septic Shock via the Cytokine Storm of a cyclone of endotoxin particles, says Pain. It has been known since 2003 that Endotoxins cause Myocarditis in 24 hours. Pain lists the diseases due to Endotoxins as strokes, heart attacks, anaphylaxis, cancer, sudden death, and fatigue syndrome.
While antivaxxers foment hysteria about nanoparticles, COVID spike proteins, mRNA, and graphene oxide in vaccines, and snake venom, it is apparently foodborne endotoxins that are carried into human cells. Neither vax proponents nor anti-vaxxers even mention Endotoxins, which fly under their ideological radars.
As Klaus Brandenburg of Germany puts it, “COVID-19 patients ‘mimic’ bacterial sepsis, and the immune response is “the mirror image of sepsis”. Moreover, “severe cases of non-COVID caused by respiratory pathogens lead to complications similar to those described…thereby suggesting that COVID-19 mortality may be the result of sepsis.”
People are Dying of Gut Permeability Not Viruses or Toxins Per Se
A study done by Greek researchers was undertaken in 2021 to determine whether COVID-19 patients presented with compromised intestinal barriers that allowed endotoxins to relocate into the blood circulation system (aka sepsis or blood poisoning) and whether intestinal barrier biomarkers were of any prognostic value in progression to severe disease (see “Intestinal Barrier Biomarker Z01 and Endotoxin are Increased in Blood of Patients with COVID-19 Associated Pneumonia”, In Vivo journal, July 2021).
A summary of this study is:
“There was no difference in endotoxin levels between patients with COVID-19-related pneumonia and patients with CAP (Community Acquired Pneumonia). In patients with COVID-19-related pneumonia, serum endotoxin concentrations were positively correlated with C-reactive protein (inflammation marker) and ferritin values (iron level in the blood). There were no significant differences in (blood) serum endotoxin and ZO1 concentrations (plaque proteins – when red blood cells meet toxins in the body they clump) between patients with severe and not severe COVID-19-related pneumonia, nor between patients who developed SRF (Severe Respiratory Failure) and those who did not. Conclusion: Patients with COVID-19-related pneumonia present intestinal barrier dysfunction leading to systemic endotoxemia. Admission values of endotoxin and ZO1 do not have any prognostic role for progression to SRF.”
Put differently, those with respiratory disease are dying of sepsis from a compromised gut, not from a virus bug nor from a compromised immune system by failure to detox. This study supports the notion of viral sepsis, but not from any virus per se but from “virulence”, meaning the capability of a microbe (endotoxin) to cause damage to its host due to (intestinal) organ failure or malfunction. In the referenced study, there was no difference in endotoxin concentrations between patients with severe and moderate pneumonia, between patients who regressed to Severe Respiratory Failure and those who did not. The only material difference was between healthy controls and those with sepsis who had multiple organ failure centered around a compromised intestinal lining which brought about systemic release of endotoxin. Even in those with multiple organ dysfunction syndrome, there was typically no bacterial overgrowth or pathology identified, but nonetheless, the clinical manifestation is sepsis.
The intestine is the “motor’ of sepsis. And the intestine depends on butyrate (the product of dietary fiber fermentation for colonocytes), propionate (derived from beta glucan from barley or oats to preserve gut lining) and acetate (the shortest fatty acid that can be boosted by apple cider vinegar for cardiac, blood and memory improvement). This might e supplemented with collagen ideally from meat (legs, feet, ears, gelatin).
No number of vaccine boosters, natural coffee enemas and detoxes, or COVID-19 emergency protocols entailing high dose IV Vitamin C, steroids, and thiamine, will make much of a difference with sepsis.
I subscribed after reading some of your reviews on amazon.
btw no big deal but there’s a missing letter b in the last sentence of the second last paragraph above. at first glance i thought it was something about vitamin e + collagen 😂
Thank you for all of your stacks. ❤️
This one definitely makes me think back to March of 2020 and how sick I got with symptoms i’ve never experienced before or after.
My husband got sick first but his symptoms were mild compared to mine and he had no breathing issues.
My cousin in law is a respiratory therapist and on day 9 of me progressively getting worse, he told me if I made it past day 10 with the breathing issues, my odds were almost 100% survival.
(I refused the hospital)
He said thats what he had noticed in patients who had the shortness of breath, weird throat cough and dizziness.
He was spot on.
Day 10 was the worst and my family thought I was going to die.
Heck even I did at that point.
I woke up on day 11 and could breathe again!
Not instant healed because I still have residual issues to this day but I knew on day 11 I was going to live.
My conspiracy theory is that the initial people like me who got so sick were the ones who had a late 2019 flu shot.
Then something triggered the injected poison. 🤷♀️